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Psychedelic drug Wikipedia In a subsequent publication, Ettrup et al. examined a series of nine structural congeners of CIMBI -5 to identify one with improved target-to-background binding. Their most promising candidate proved to be Cimbi-36, which was further characterized by Finnema et al. as an improved agonist PET radioligand for in vivo imaging of 5-HT2A and 5-HT2C receptors in the nonhuman primate brain. The PFC is the executive area of the brain where incoming sensory information and affective output from the limbic areas converges, creating our sense of awareness of our environment and being involved in higher cognitive functions. The PFC in primates coordinates actions such as complex cognitive and affective functions, with many reciprocal fiber connections from other neocortical areas, as well as with numerous subcortical and limbic structures. Low doses of 5–75 μg/l LSD in the tank water had no effect on zebrafish behavior, although 100 μg/l produced nonsignificant trends